Officially, no. Unofficially, since Catalina there is a workaround to get system wide stereo-paired audio. Open a video in the TV app, select your stereo-paired HomePod via the App's Airplay option. Pause video but do not disconnect the audio. Open the Audio MIDI Setup app in Applications>Utilites. Airplay icon appears in the left hand list of audio devices (only when activated via the TV app step earlier). Right click on the Airplay icon and select Use this device for sound output. Your Mac volume controls can be used to adjust volume as normal. Music app can be used instead of TV app but it does not seem to be as sticky - after a period of non-use the app disconnects from airplay and you also loose your system wide workaround connection. Have not experimented with the Podcast app to see how sticky it is or not.
I even use this to play my vinyl over my stereo-paired HomePods 😁 although that involves having an audio interface device to convert your analogue signal to digital and a paid app called Airfoil. You also need an additional step in Audio MIDI Setup where you click the "+" icon and add Aggregate device and tick Airplay. Then in the Airfoil app preferences you select play computer audio through Aggregate Device. Drop that needle and two seconds later hear it on the HomePods. Unfortunately HomePods are limited to 16bit (CD quality sound) so my full 24bit signal conversion doesn't make it that far. Not for the analogue purists perhaps but still a lot of fun.