There seems to be a lot of shrugging this off as "its just Apple", they just represent 1% of Intel's business.
But there are a few points I'd like to raise:
1) This is really high profile and embarrassing to Intel
2) If Microsoft got it together with their Windows on ARM ecosystem, Intel could be in huge trouble
3) Most of Intel's sales are to servers in the cloud. For 2 years, AWS has had both Graviton (their own ARM processors) and AMD processors in their offerings, whereas they were previously Intel exclusive.
No matter which way you look at it, Intel has been struggling and customers are beginning to move on. Its one thing to switch to AMD, but switching processor architectures is a long-term loss due to the work generally involved.
And of course these days, cloud-based software is usually agnostic to what the client is running (its usually javascript/html or cross-platform client development tools),and agnostic to what the servers are running because most developers don't write code in assembly or even C for that matter if they are writing for the cloud.
Intel losing their grip on the server market should be even more concerning to them. Its where all the money is for them.