Look at your brain as a CPU with a finite GHz capacity.
Look at your ears as a peripheral with min/max specs. Biologically, the specs of the ear on
the average person can't detect the difference between lossless and compressed music (mp3 192/384).
For the 5% that have ears with the better specs, they will need their brain undistracted to really hear it. When that brain gets immersed in visuals, like from a VisionPro, any Hollywood executive can tell you that audio is supportive to visual. You'll loose brain capacity to processing the visuals over using that brain capacity to enjoy the difference between lossless and compressed audio.
If you really want the
best sound, I hope you a) belong to the 5% that has super ears and b) have the budget to buy true high end audio equipment.
Enjoy.