It's funny, all this talk of resolution independence and yet OSX is the only major desktop OS where you cannot change the size of the system font!! You know, the font for the menu bar across the top of the screen, and other assorted menus and dialog boxes. You can't change it!! Stupid!! I have a brand new Mac Mini attached to my Sony XBR 1080p television, yet I have to keep it set to 720p. Why? Because at 1080p, the menus are too tiny, I can't read them from the couch, even with my glasses on. And did I mention that you can't change the system font size?!!?!?!?! They better fix this crap in Lion.
Before you wet yourself with anger, let System Preferences be your friend, especially "universal Access." Apple has had this as part of their system your whole young life.