1) The Touch fits in most hands perfectly that I've seen & w/o any contorted or awkward angles. That is the essence of ergonomics. If it was difficult to handle it wouldn't be as popular as it is. Consumers don't make poorly designed products sales hits.
2) The Zune interface has shown its hand in the PR pic. Part of the menu is even cut off at the bottom. How is that good interface design? Also it could be much more user efficient w/ smaller text and adding icons, allowing more activities on a single screen w/o having to scroll down. The Zune PR pic looks like the interface is designed for people with sight problems.
3) There are many "remote" apps in the App store, many free. They can control and sync w/ Macs, control iTunes, Powerpoint, Keynote, Boxee, and, oh yeah, the XBox. That's just for starters. So I'm not sure how you can say the Touch is weak on connectivity. Also the Touch works w/ Macs and Windows. The Zune is Windows only, so I'd say, yes the Zune is weak.