Disconnect the mouse, then use dry unwaxed paper to push the ball in and roll it in all directions. Kitchen roll is perfect for the job. You'll see blobs of grease start to break off. Wipe these away with the paper to make sure they don't go back down the hole. Do this in all directions for a few minutes until the mouse ball feels rough (You should then remember this is how it felt in the beginning before you got your greasy mitts on it). Repeat if necessary. Now when you move the mouse ball normally, you should hear the clicking noise to show it's working correctly with the rollers. Plug it back in and the scroll action should work again.
Remember, dry unwaxed paper. Don't use a moist cloth as Apple suggests.
Hello folks!
I did this:
1- I pour 3 drops of WD-40 in the gap of the little track ball and turn the mighty mouse upside down for avoiding contact of the liquid with the inner electronics.
I just started to have the same problem, and your solution worked. At first i thought it might be from a recent download (one of the many things that happen after an upgrade) but I just fixed it using your method. ThanksI recently developed a scrolling problem with my Mighty Mouse. It started to only vertical scroll in one direction. I reinstalled the software and it did not help. So, I called Apple tech support. While waiting on the line, I decided to press quite hard on the scroll button and try to scroll. That cured the problem, after that it only required the normal light touch to work properly. I do not know what was the cause of the problem, maybe dust(?), in any event it is working fine now.