As a biased Michigan State fan, I think the West bracket 1-4 or 1-5 is stacked more so than other brackets (**as long as there are no upsets and we know how that goes). I would have to say the weakest 1-5 looks to be the Midwest.
Midwest: UNC has proven to be beatable, but also deadly with talent. Kansas is solid. Georgetown is good, but not necessarily been elite. Also recent tourney fails. Michigan got whooped hard by OSU in the B1G. All their best wins came at home. Temple? Temple.
East: Syracuse is legit, but hasn't done much come tourney time lately. Ohio State lacks depth, but has outstanding defense and first 6. Florida State probably over-ranked at 3, but can be deadly (see: UNC, parts 1 and 2). I think Bo and Wisconsin aren't suited for postseason play, see: past few years since Seth Curry/Davidson when they actually advanced some. Vandy: potential sleeper, could make some noise.
South: Kentucky - stacked, young. Duke - peaks and valleys, can never count them out though. Baylor - still hasn't gotten over their soft/overrated label imo. Indiana - also like Michigan, only won big at home. Wichita State - sleeper/shocker of the area, but will run into Kentucky, ouch.
West: MSU - not quite as talented, but reasonably deep, solid leadership, Izzo. Mizzou - probably hardest team to match up against, chip on their shoulder (8th ranked team, seriously?). Marquette - quiet (nationally at least) reception to a great Big East season. Louisville - bi-polar team, don't know what you're going to get, but can grind out games. New Mexico - solid defensively, experienced, upstart team.
Either way, looking forward to actually sitting down and focusing on my bracket submissions later.