What does that have to do with anything? First I have a Pre and a Macbook and I STILL HAVE iTunes synching. I just won't update to 8.2.1 since iTunes 8.2 works flawlessly with the Pre (music, playlists, photos, videos, podcasts,etc.).
Also it's very freeing going from an iPhone to a Pre since it's all OTA. My google calendar/contacts all sync with my Address Book/iCal via Google and over the air. My email (Google and Yahoo) are both push IMAP and reliable. I can download music from Amazon Mp3 on the device. I can purchase apps on the device. I can upgrade to new firmware/software releases over the air too.
Why do I need to use iTunes again?
You can sync google calendar and contacts with the iPhone just the same way, OTA with Google's free Exchange server.