anyone tried 10.10.3 beta? Is it fixed?
I'd like to know that as well. But honestly, I'm not getting my hopes up. I don't think it's going to get fixed. Mission Control has traditionally lagged with Macs that don't have overkill graphics power (and 5K is really a lot....)
I got used to it. It's ok, I mean, you can still use Mission Control, the response time is the same, it's just that the animation is jerky when there are multiple windows. Preview as well, and even some window resizing and scrolling with large amount of large thumbnails

That's just how it is.
The good part is - that's because OS X is simply demanding in this way. Windows 8 flies on the thing and so do the apps (and games in normal resolution).
At least the M290X doesn't get so hot, and it's quite a fine gpu. But, as I said, I expect Mission Control to be laggy until I get a new iMac

Just deal with it, it's not like the computer is generally slow, quite the opposite! But I really don't think the lag is a "software issue" as people hope it to be.
Oh and, my guess is, that if it ever *does* get fixed, it's going to be with 10.11, not in Yosemite.