Unlikely.
After 12 years of college, one thing I learned is that physical textbooks are themselves tools above and beyond their content. They are repositories for sticky notes and folded paper outlines, dog-eared pages, highlights, notes in margins, broken bindings that open to the most important pages, tabbed pages, resources for open book exams, props for looking important in the coffeeshop, visual reminders of how far the semester has progressed, collectibles, resources to be saved and put on your office shelf for occasional reference once you get a job, etc.
At best, an ebook reader will achieve only a few of these purposes.