I'll be long gone by then (b. 1943) but am planning on seeing what happens in the next 20 years (my mom lived to 97).
Here's what strikes me. Back in the late 80s (almost 30 years ago) I was working with another guy, writing FORTRAN for VMS machines, working entirely with the command line, and doing well. My programming partner's younger brother was immersed in the Windows environment, with databases, etc. and just getting into doing back end internet stuff.
We were sitting around once talking about the new Intel processors and how fast they were getting, and I asked the PC guy what he thought all those cycles were going to be used for. He didn't hesitate: "the GUI," he said, "the GUI."
What I'd like to see before I can't see anything any more would be an extremely advanced UI. Voice commands would be good, gestures (in the air) nice too. But more than anything, I'd like a UI that easily learns how I work, how I use my computer, what I like to see displayed, and so on. Sure, we can set those things up ourselves, now, but they don't adjust themselves automatically or responsively.
I'd like to say, "I need to look around on the NAS," and be asked "which volume," and say, "I don't know . . . show them all," and look, and then say, "Just Saddle Road Press, and I want to see stuff from 2014 or 2015, no poetry just fiction, just the InDesign files, put the front matter up for me, I'll tell you when I want the next one . . . ."
So that's a wish rather than a prediction. If I have a prediction, it's that the kind of thing I'm talking about will show up before I die. Or can't work, whichever comes first (here's hoping death precedes being unable to work).