If what i learned some time ago is still true then...
You can not use a retail DVD for installs and have to rely on hacked install CD's
Can not use a "vanilla" kernel, and have to wait for a new custom kernel or hacked security upgrade (or edit the install script yourself) everytime you want to upgrade.
As i like to keep my system up to date it is easier (and more secure) for me to go with hardware that matches Apple's offerings to a certain degree. That is why i say - If you want a Hackintosh go Intel.
Yea thats true, but with software like AMD Software Update you can install everything without much trouble.