My handbag for the daily commute in NYC used to have a wallet, a change purse w/ subway tokens in it, pen, little notepad, travel pack of facial tissues and a few toiletries, that's about it.
Now I'm retired and supposedly leading a simpler life, but I can't go anywhere without a totebag carting all kinds of other stuff like iPad, iPhone, iPod touch and an iPod Nano w/ FM radio, plus their assorted cables and a charger, earbuds, keyboard, bluetooth speaker, yada yada, it's all Apple's fault.
I do actually have a go-bag though, it's out in the car in winter. A duffel with jeans and a copy of warm everything else from unders on up in it -- since if the house caught fire and i managed to escape it would be nice not to be outdoors in nearly my "birthday suit" when it's ten below zero. There's other stuff like a spare parka, gloves, scarf, hat, a fleece blanket, utility tools and well-wrapped energy bars and sports drink mix packets in some plastic bins in the car's trunk. I don't lock the car in that season either and the key's in the ignition, snow shovel and brush on the deck ready to roll. The deep winter's no joke here. I figure as long as i have that stuff ready, maybe I won't need it.