iGary said:NOT with software.
I'm not sure if that's true. I've used my educational discount in the San Francisco store (or was it Emeryville?) on Creative Suite and Final Cut Express. That might be an exception to the rule, but since there are fliers that say you can use your educational discount in-store and I don't recall any "no software" disclaimers," so I guess it depends on which store we're talking about.