I have to honestly say no, and I have a 6 plus. My biggest fear in preordering was that the plus would be too unwieldy. But I have to say my biggest surprise so far has been how "unbig" the phone feels so far. I probably have bigger than average hands but not huge, I wear size large gloves. And I have to say I can do everything with this phone one-handed that I could do with the 5S without using reach ability or making any other allowances. I will say that the one thing I do it that instead of holding it in my palm as I would earlier iPhones i have this resting more on my fingers and that gives my thumb more room to operate, but it's quite comfortable and I really think the thinness of the device is what makes it that way, I'm not sure if it will be the same after adding the bulk of a case, we'll see.