Try doing this with a machine that has only 1 port or one that isn't running OS X v10.10.3... The support for this is both hardware and software; not a very reliable solution as we've seen many times in the past. These things might change in the future, but that is not the main problem.
It will take up all of its TB ports (2) and thus you won't be able to use any TB device. There are no external TB devices with at least 3 TB ports which you need: 1 for connecting to the machine (or other TB device in front of it) and 2 for connecting the display. Using both TB ports to drive 1 display is like turning your MBPr 15" into the MacBook. As you can read from reviews and the MacBook subforum here quite a lot of people dislike that.
The Mac Pro is the only Apple machine where this display could still have potential in the future (it still takes up 2 precious TB ports but at least you have 4 more). The other future is with ordinary PCs but that's not the scope of this website and its community
Let's be honest here. The way 5K is done atm is just ugly, it's not proper. Apple can get away with that with the iMac because it is an all in one device, Dell can get away with it because the PC market is more open for those kind of tricks.