I think almost the opposite: mobility is the big draw for me- great big screens I can summon while on the go. My #1 imagined use is for many long flights, when I'd like my desktop-sized screen R.E. vs. only 16" in a laptop. On the plane, on the train, at the hotel, when given a few hours at a client's office, etc- all seem like ideal times to summon the bigger screen to get things done. If I'm done, the ability to watch some movies on a giant screen and "wash away the plane" seems appealing too.
However, when at home or work, I imagine that much like the MB, it is in bag the majority of the time. I have a big screen TV at home for movies. It has great surround sound. When others are around, we'll watch on the home theater together.
When at work, I already have the big screen desktop monitor and the more powerful desktop Mac & PC connected to it. I'll use those and their big monitor instead. When I need to collaborate with someone, we'll collaborate on the big, physical monitor on the desk.
All that great stuff is anchored at those locations. I can't bring the giant TV or surround sound speakers onto the plane. I can't balance a 40" ultra wide on a tray table. All of that kind of tech is ideal when I'm where they are anchored. It's when I am AWAY from those spots where Vpro seems to offer enormous utility... much better than making do with a tiny phone screen, slightly larger tablet screen or even a 16" MB screen.
Does that mean I see no applications at home or office? Of course not. It very well may have great uses in either or both. But if that is the bulk of one's focus/time, I suspect they already have big screens and great computing tech at both locations. I see less purpose in Vpro if I had quick & easy access to my home or office setups at just about all times... UNLESS I didn't already have such equipment and might consider seeing if this could be a viable substitute for some of that. While I lean positive on Vpro, I lean negative on it being a substitution product for the traditional products. But maybe it works for someone's situation(s) in lieu of a home theater setup or in lieu of a traditional desktop office setup. I imagine it would not work as well... but maybe "good enough" for some people.