I was born in San Diego, CA and moved to IN in 2003 or so. My father and I moved here to be closer to family and because of the university in town. Luckily the university brings more diversity and tolerance to the town than what would be seen in the rest of the state.
I don't plan on ever moving back, but who knows. I definitely visit often though. The weather doesn't compare (as in I like San Diego's better)! It's nice having real seasons sometimes though....