While I don't see myself ever relinquish abandon the platform of which I've always been a great fan since the first Mac OS X iteration, I have given up on using certain apps the platform bids, such as iPhoto / the Photos app. Reason: extremely unreliable updates that would eat up thousands of my photos, as well as reassign keywords from one random image to another.
Apple Mail: same story - over the years, it has gobbled up and deleted tens of thousands of my incoming and outgoing emails (stored offline mostly, but online on occasion, too), drafts, archives, whole postboxes, etc. A lot of things of mostly sentimental and occasionally practical value have waned into thin air, thank you, Apple!
The Notes app: same story, although it appears to be more stable in that regard today than it was between updates from .Mac to MobileMe to iDisk to iCloud. Still, to this day it is as choke full of formatting bugs as ever.
…and now this. Come on, Apple! Enough of this rubbish!