I can see why people might have a hard time adjusting to the high-res screen, but I don't understand the aspect of eye-strain... Currently, I am using a PC (yes, shame on me), but I am very much considering a MacBook Pro! And since I have been using an LCD screen with a native resolution of 1680 x 1050 for about two years (my current laptop), I am planning on getting the high-res MacBook Pro (haven't decided on the question of glass vs. anti-glare).
I am very happy about the resolution of my laptop screen and I have no problems whatsoever with text or eye-strain. This brings me to the essense of my post: Will the 1680 x 1050 resolution look any different on a MacBook Pro 15" than it does on my DELL Precision 15" (yes, I am about to throw it out - it's terrible!)?