It would only break lame applications, and those developers better fix them. I already use HFSX+ and the only applications I have trouble with are Photoshop and Warcraft 3, I've solved both by making an HFS+ image which I've installed them into instead.I know, however I read that ZFS would incorporate some changes that are not compatible with HFS+, like mandatory case-sensitivity. That could break some applications, the same way that UFS currently does. It could also break software doing direct disk access such as backup software. It would in any case require some good testing. Only showing it to the world on release day would in my opinion be a cause for major problems.
It's not like USING THE ****ING SAME CASE ON YOUR FILES NAMES isn't as much of a challange as switching CPU archs all the ****ing time ;/, or Carbon/Cocoa/.. for that matter.
How hard can it be to not try to read War3.mpq or whatever when the files name are war3.mpq!?! Not very.