I'm a little disappointed that the current version of aMSN isn't working with it, as that's what I use to video chat with my partner when they're away (which is a lot, and for some reason I've never been into the Skype thing

), but I might give the next beta version a shot then.
I also hope that there's an update to Vuze relatively soon, but it's not like not using it is going to kill me
For me, the ones I'm most 'upset' with is Growl's memory leaks, as I use that a lot with Adium and Last.FM, as well as the total incompatibility with OnyX altogether - albeit not unexpected as it IS a new OS, and no doubt there'll be an update soon.
Anyway, as of several hours ago I've had SL on preorder, can't wait to give it a try even if I can't use some of my favourite apps
Oh, and yeah, on topic

it's looking more like a new OS and not just a simple 'upgrade' of Leopard to me since I read that Apple page, they really have packed a lot of stuff into it even if it's not immediately noticeable. I remember seeing a graph a couple weeks ago outlining how much they've cut down the sizes of some apps, and I'm absolutely amazed with how they've been able to achieve that. Progress is not necessarily adding 'awesome new features' - progress is optimisation and fine tuning, and hopefully that's the key to Snow Leopard's success.