Haven't used it in mail, yet. Viewing pdf has been smooth for me. MBP late 2011.
Its just as smooth as in safari for me system-wide...except iTunes as others have mentioned.
Thanks for your input. Looking back at Apple's WWDC keynote Craig Federighi did say OS X Mavericks will have "System-wide Core Animation Accelerated scrolling" which is basically what Safari and other apps should be using.
Digging deeper, I checked out Apple's Core Animation documentation:
https://developer.apple.com/library...nimation_guide/Introduction/Introduction.html
It reads "This automatic graphics acceleration results in high frame rates and smooth animations without burdening the CPU and slowing down your app." So it sounds like it's mostly GPU accelerated.
Core Animation is basically an API that lets OS X and iOS produce animated user interfaces. This has always existed in OS X since 10.5 Leopard. In addition to basic animations such as Mission Control, Apple has also decided to use it in the form of scrolling in OS X Mavericks.