Properly configured, it's automatic with Logitech's mice. Plug it in and hopefully it doesn't lock onto another channel, or the other's base-station. This problem is amplified when two or more wireless mice are with in a few yards of each other, because sometimes the new one will lock onto the strongest source, even if it's not its own.
My Cordless Logitech mouse and my VX400 have been pretty good when running along side my MX1000, much better than my old MX700, but it's never problem free. Sometimes just the second mouse will cause my mouse's tracking to freak out, until I reconnect one of them.
Even wifi routers and phones can cause problems with these mice. Moving to a Aiport Extreme helped out my situation some, but I had to get rid of my 2.4 Ghz phones, as they would lock onto the strongest source. There are only so many channels available. It would have been nice if these mice and my old phones had allowed me to pick their channel, that would have eliminated some of the problems I've encountered over the years.
Even with Logitech's newer Revolution, it's still prone to the same problems, so unless you're talking about the most recent mice, like the Mamba -- which you mentioned you don't have -- which has some new method of finding a clear channel, there has not been a wireless mouse that hasn't been prone to interference, and even the Mamba is up in the air, as it's still new.
If my primary PC were in another room, I might have bought a wireless mouse for it, but since I'll sometimes bring it to LAN parties and more importantly it's sharing the same desk as my MacBook Pro. Choosing a wired mouse for my PC was one less headache for me to deal with. I'll keep the wireless one on my Mac, as that's what I use a majority of the time.
