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I've read a fair bit that seems to suggest that the AZ (and I guess the other same tech ones - J&J) seem to be better at creating a T cell response, which AFAIK is quite long lasting compared to the antibody response (?). I'm no expert so I won't try and expound any further - I will just leave a link to an FT article here (and there are many others if you google.) I guess this is why there's so much thinking going on about mixing vaccines.

This seems to coincide with my own anecdotal experiences here in the UK that has lots of AZ vaccinations. When we were unvaccinated (through the first two waves but particularly during the second) I knew lots of people who got infected and also knew some people who died. This third wave (despite being a nastier Delta variant) feels a lot more remote as although there obviously are still a lot of infections according to the stats etc, I'm really not seeing much around me and I haven't as yet heard of anyone I know (even vaguely) being really ill, hospitalised or dying. (Lots of people are getting pinged by the app but that's a different discussion). Mind you, I don't know any vaccine refusers even among my daughters peer group who are all about 18. I do know of a few people who said they were going to refuse but when it came to crunch they all quietly seemed to change their minds.

Now, I appreciate this is completely subjective and I'm certainly not saying we're out of the woods so I'm continuing to be very careful (as I'd advise everyone else to be) but to my mind it's a great advert for taking up a vaccination. In my little bit of the world they seem to be working really well...

It depends on where you are, the response of your state and local government, your employment situation, and luck.

I only personally know two people that got COVID. My manager (and her family), and someone from my conservative religious circle. There are a total of 316 cases in my state right now and it has done well through the whole pandemic compared to the average state. My extended family is very cautious regarding health and, apparently, my neighbors are as well. This may have something to do with income and education.

If you can WFH, then you have advantages over people that can't.

My sister moved from MA to VT as she was rather freaked out at what was going on in MA - population density is definitely a factor.
 
I've read a fair bit that seems to suggest that the AZ (and I guess the other same tech ones - J&J) seem to be better at creating a T cell response, which AFAIK is quite long lasting compared to the antibody response (?). I'm no expert so I won't try and expound any further - I will just leave a link to an FT article here (and there are many others if you google.) I guess this is why there's so much thinking going on about mixing vaccines.

This seems to coincide with my own anecdotal experiences here in the UK that has lots of AZ vaccinations. When we were unvaccinated (through the first two waves but particularly during the second) I knew lots of people who got infected and also knew some people who died. This third wave (despite being a nastier Delta variant) feels a lot more remote as although there obviously are still a lot of infections according to the stats etc, I'm really not seeing much around me and I haven't as yet heard of anyone I know (even vaguely) being really ill, hospitalised or dying. (Lots of people are getting pinged by the app but that's a different discussion). Mind you, I don't know any vaccine refusers even among my daughters peer group who are all about 18. I do know of a few people who said they were going to refuse but when it came to crunch they all quietly seemed to change their minds.

Now, I appreciate this is completely subjective and I'm certainly not saying we're out of the woods so I'm continuing to be very careful (as I'd advise everyone else to be) but to my mind it's a great advert for taking up a vaccination. In my little bit of the world they seem to be working really well...
I know a few people who haven’t booked their vaccine appointments despite being offered. The daily dose administered counts suggest we are running into a significant problem with vaccine hesitancy over the last couple of weeks though as it’s dropped off substantially.
 
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Sure, I completely appreciate YMMV. Different people will have different experiences and it's unrealistic to expect absolutely everyone to take up a vaccine. For example here's always plenty of risky behaviour particularly among young men (try getting car insurance at 18 as a male driver). I'm still impressed by how well the vaccines seem to have worked - my personal experience (I know of a few deaths etc) is that they seem to have taken my bit of the world from being in the eye of a storm to being on its periphery and I still think that's a really good advert for the vaccines. Perhaps that will change soon but we'll see.
 
The other day I glanced at a story about Pfizer developing a specific medicine to treat Covid-19. (Very likely lots of pharmaceutical companies are working in this direction.) The imperfections of the vaccines - uptake/availability, efficacy, etc. - meaning that there will continue to be large numbers of people infected.

From my point of view, I feel more comfortable having had a vaccine, despite the discussion about it only having an emergency use authorisation, than a new medicine. The number of recipients of the vaccine is now huge. It will take a long time for any therapeutic medicine to achieve substantial field experience.

Some people are concerned about the possible effects of the vaccines on fertility. Have to say, whilst almost entirely ignorant of details, I suspect that Covid-19 itself, especially if followed by long Covid, is likely to have a more significant effect on fertility and pregnancy than the vaccines. (These are, of course, considered as population statistics - which might not apply to individuals.)
 
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Antibodies from Sinovac's COVID-19 shot fade after about 6 months, booster helps - study​


For participants receiving two doses, two or four weeks apart, only 16.9% and 35.2% respectively still had a level of neutralising antibodies above the threshold six months after the second dose, the paper said.

When participants in some cohorts were given a third dose, about six months after the second, neutralising antibody levels after a further 28 days had increased around 3-5 fold from the levels seen four weeks after the second dose, the study showed.

 

Antibodies from Sinovac's COVID-19 shot fade after about 6 months, booster helps - study​


For participants receiving two doses, two or four weeks apart, only 16.9% and 35.2% respectively still had a level of neutralising antibodies above the threshold six months after the second dose, the paper said.

When participants in some cohorts were given a third dose, about six months after the second, neutralising antibody levels after a further 28 days had increased around 3-5 fold from the levels seen four weeks after the second dose, the study showed.


What was Sinovacs efficiency to start with, and is it traditional vaccine like JnJ or like the Pfizer and Moderna? Honestly not sure on non US available vaccines. Not that I am "'Merica!" just there was no chance for me to take the other vaccines so I only looked into the 3 I could get.
 
What was Sinovacs efficiency to start with, and is it traditional vaccine like JnJ or like the Pfizer and Moderna? Honestly not sure on non US available vaccines. Not that I am "'Merica!" just there was no chance for me to take the other vaccines so I only looked into the 3 I could get.

No clue. But antibodies do seem to drop with time. There's clearly some issues with what the Israelis are seeing.
 
Revised CDC guidelines coming out at 3 PM Eastern. I've heard rumors that the recommendation is masks for kids in schools.

I wore a mask to a restaurant today (takeout). We were the only people in the store wearing masks. Nobody batted an eyelash. The number of cases in our town is at 7 as of yesterday. It was 0 a few weeks ago. State is at 368. 155 a few weeks ago. The gym I attend has a camp and daycare. There are typically over 100 children there on weekdays from 9 AM to 3 PM. If we get one child or adult and it spreads, our numbers will mushroom like mad. Town vaccination rate is at 54%. 54% was enough until Delta.

We have an average of 40K cases a day and projections are that we could shoot to 200K cases a day in a few weeks.

This seems like 2020 all over again.
 
Looks like it is official. I hope that they can get EUA on this pretty quickly.

*PFIZER SHARES PLANS FOR NEW COVID VACCINE FORMULATION IN SLIDES
*PFIZER: FIRST BATCH OF DELTA-FOCUSED COVID SHOT ALREADY MADE
*PFIZER TO LAUNCH STUDY OF DELTA-FOCUSED VACCINE IN AUGUST
 
We have an average of 40K cases a day and projections are that we could shoot to 200K cases a day in a few weeks.
This seems like 2020 all over again.
Thankfully, we should not get even close to the number of deaths or long COVID of last year thanks to the vaccines and the fact that it's the younger that get infected. Which brings home the point that vaccines do work and are important.
 
Thankfully, we should not get even close to the number of deaths or long COVID of last year thanks to the vaccines and the fact that it's the younger that get infected. Which brings home the point that vaccines do work and are important.

The recent big discovery, though, is that the fully vaccinated can carry the heave Delta viral load and spread it to the unvaccinated. Hence the new CDC guidance.

I had a look around to see if Pfizer is recruiting yet for the new Delta vaccine and there's nothing on their Clinical Trials website yet.
 
The recent big discovery, though, is that the fully vaccinated can carry the heave Delta viral load and spread it to the unvaccinated. Hence the new CDC guidance.

I had a look around to see if Pfizer is recruiting yet for the new Delta vaccine and there's nothing on their Clinical Trials website yet.
Honestly, I am more concerned about this:


Deep in the article: "About 60% of the more than 42,000 employees of New York City's public hospital system are vaccinated, Mitch Katz, who heads the nation's largest public healthcare system, said on Wednesday. Across New York City, 70% of hospital staff have received both doses of the vaccine, state data shows."

You're telling me that 17,000 public health workers are not vaccinated? And they're in what was the worst-hit city??
 
The recent big discovery, though, is that the fully vaccinated can carry the heave Delta viral load and spread it to the unvaccinated.
Honestly, by now virtually everyone in the US had opportunities to get vaccinated. Stocks are available in huge amounts. I don't want to sound harsh, but after a while it becomes a conscious choice, which will carry whatever risk those individual decide to take. Kind of like non-vaxers for other viruses...
 
Honestly, I am more concerned about this:


Deep in the article: "About 60% of the more than 42,000 employees of New York City's public hospital system are vaccinated, Mitch Katz, who heads the nation's largest public healthcare system, said on Wednesday. Across New York City, 70% of hospital staff have received both doses of the vaccine, state data shows."

You're telling me that 17,000 public health workers are not vaccinated? And they're in what was the worst-hit city??

Mass General Brigham told its 80,000 workers Thursday that it will be requiring them to get vaccinated against the coronavirus. More than 85 percent of Mass General Brigham employees have already been vaccinated—one of the highest rates nationwide among health care systems.


This article is a month old. This is also where I get cancer care.

Tufts said Wednesday nearly 90% of its employees are vaccinated, while Beth Israel Deaconess estimated around 85% of its employees are, too.

The Tufts and Beth Israel Deaconess groups are going to require all employees, even those that don't face patients, to be vaccinated.

I think that MA has the highest vaccination rate in the country.
 
Honestly, by now virtually everyone in the US had opportunities to get vaccinated. Stocks are available in huge amounts. I don't want to sound harsh, but after a while it becomes a conscious choice, which will carry whatever risk those individual decide to take. Kind of like non-vaxers for other viruses...

Nobody likes to come across as being coercive.

So employers get to be the bad guy.
 
I think that MA has the highest vaccination rate in the country.
That would be Vermont according to the CDC. New England is doing great! Here's today's infographic from the NY Times:

Screen Shot 2021-07-28 at 12.24.41 PM.png
 
That would be Vermont according to the CDC. New England is doing great! Here's today's infographic from the NY Times:

View attachment 1812097
Thank you for sharing the table. The numbers actually look much better than what I expected.
Lowest state (both shots, that is fully vaccinated) is at 42.8% of its population (Alabama).

This is by far the most important table considering mortality rate. It explains why death rate is not following the new cases trend:

1627489806428.png

More than 2/3 of the adults in the US got their shot. There is lots of work to do still, but not bad, to be honest.

If we're averaging 588,000 new shots per day we will reach 75% and 90% of the adult population fully vaccinated quite soon!
 
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I think both Pfizer/BioNTech and Moderna want their "booster" shots be ready for EUA release by late September 2021. And Novavax to make sure their vaccine is effective against the Delta and Lambda variants when it gets EUA clearance by early October 2021.
 
I think both Pfizer/BioNTech and Moderna want their "booster" shots be ready for EUA release by late September 2021. And Novavax to make sure their vaccine is effective against the Delta and Lambda variants when it gets EUA clearance by early October 2021.
I did my first shot in December 2020, so I can't wait for the booster! I'll be first in line (well, maybe second in line just to see what happens to the person in front of me :) )
 
As a healthcare provider I can say a third shot (at a minimum) is absolutely going to happen. It will take some time to go through the proper trials and authorization process, but I think it’s inevitable. Pfizer’s 3rd shot recently released info from their study is only looking antibody levels, which doesn’t necessarily translate to real world efficacy. So they have a lot more work to do before they can market such a product.

The problem however is that a booster is not going to be particularly effective longterm when you consider that 1/3% of eligible America doesn’t want the vaccine plus (currently) children under 12 are not eligible. Plus much of the world doesn’t have any significant percentage of their population vaccinated.

While it’s true that even with the full vaccinations under the current protocols makes hospitalization and death extremely unlikely, the problem is with only 40% efficacy, regardless of how severe the breakthrough cases are, there is a potential for mutations that make the virus resistant to the current vaccines, which could mean even more breakthrough cases and potentially worse symptoms/outcomes. Mutations can still occur in vaccinated populations if breakthrough cases occur. It’s a very slippery slope.

The faster we can get everyone vaccinated, the better. I agree with @yaxomoxay that for 99% of people at this point not getting the vaccination is a choice. And with hundreds of millions of people vaccinated and basically one in a million chances of adverse effects (that may also occur if infected with the actual virus) and the risks of the infection itself, hesitancy in my mind is ridiculous. The problem is with such a high percentage of the population forgoing vaccinations, it’s entirely possible it will render the current vaccines even more ineffective.

I’m not sure how to convince people how to get vaccinated that don’t want to. Some people may have to see people starting to die around them. I do think the government (state, federal, and local) needs to get more creative with incentives, education/outreach to individuals and social institutions (ie churches), etc.

I believe in patient autonomy, but the consequences here are significant and extend well beyond the individual. Workplaces have long been legally authorized to mandate vaccines. It took my Hospital until late June to mandate the vaccine (about 15% were not vaccinated). I think it would be interesting if Insurance companies tried to tell their subscribers if you’re eligible and not vaccinated by D-date, we won’t cover your healthcare costs if you’re hospitalized for COVID. Not sure that would hold up legally but it would be interesting to explore.

It’s just crazy to me that with with all the deaths, hospitalizations, and reported longterm effects that people think getting the vaccine is more dangerous.

As a HCP I was among the first people in the world to get the Pfizer vaccine in the world… like a week before Christmas 2020. As someone in good health in my early 30’s I’m not so concerned about me getting severely sick- statistically it’s quite unlikely. I was more concerned about all of those more vulnerable and potential mutations creating a more virulent or dangerous strain. I think that’s how young, healthy people need to look at this.
 
Mass General Brigham told its 80,000 workers Thursday that it will be requiring them to get vaccinated against the coronavirus. More than 85 percent of Mass General Brigham employees have already been vaccinated—one of the highest rates nationwide among health care systems.


This article is a month old. This is also where I get cancer care.

Tufts said Wednesday nearly 90% of its employees are vaccinated, while Beth Israel Deaconess estimated around 85% of its employees are, too.

The Tufts and Beth Israel Deaconess groups are going to require all employees, even those that don't face patients, to be vaccinated.

I think that MA has the highest vaccination rate in the country.

It’s pretty crazy that 10-15% are unvaccinated. In my experience however working in healthcare in Massachusetts, the majority of this population are not actually medical staff. To my knowledge it’s mostly people like receptionists, custodial staff, people who work on the business ends of things, etc. There are very very few doctors and nurses who are not vaccinated.
 
As a healthcare provider I can say a third shot (at a minimum) is absolutely going to happen. It will take some time to go through the proper trials and authorization process, but I think it’s inevitable. Pfizer’s 3rd shot recently released info from their study is only looking antibody levels, which doesn’t necessarily translate to real world efficacy. So they have a lot more work to do before they can market such a product.

The problem however is that a booster is not going to be particularly effective longterm when you consider that 1/3% of eligible America doesn’t want the vaccine plus (currently) children under 12 are not eligible. Plus much of the world doesn’t have any significant percentage of their population vaccinated.

While it’s true that even with the full vaccinations under the current protocols makes hospitalization and death extremely unlikely, the problem is with only 40% efficacy, regardless of how severe the breakthrough cases are, there is a potential for mutations that make the virus resistant to the current vaccines, which could mean even more breakthrough cases and potentially worse symptoms/outcomes. Mutations can still occur in vaccinated populations if breakthrough cases occur. It’s a very slippery slope.

The faster we can get everyone vaccinated, the better. I agree with @yaxomoxay that for 99% of people at this point not getting the vaccination is a choice. And with hundreds of millions of people vaccinated and basically one in a million chances of adverse effects (that may also occur if infected with the actual virus) and the risks of the infection itself, hesitancy in my mind is ridiculous. The problem is with such a high percentage of the population forgoing vaccinations, it’s entirely possible it will render the current vaccines even more ineffective.

I’m not sure how to convince people how to get vaccinated that don’t want to. Some people may have to see people starting to die around them. I do think the government (state, federal, and local) needs to get more creative with incentives, education/outreach to individuals and social institutions (ie churches), etc.

I believe in patient autonomy, but the consequences here are significant and extend well beyond the individual. Workplaces have long been legally authorized to mandate vaccines. It took my Hospital until late June to mandate the vaccine (about 15% were not vaccinated). I think it would be interesting if Insurance companies tried to tell their subscribers if you’re eligible and not vaccinated by D-date, we won’t cover your healthcare costs if you’re hospitalized for COVID. Not sure that would hold up legally but it would be interesting to explore.

It’s just crazy to me that with with all the deaths, hospitalizations, and reported longterm effects that people think getting the vaccine is more dangerous.

As a HCP I was among the first people in the world to get the Pfizer vaccine in the world… like a week before Christmas 2020. As someone in good health in my early 30’s I’m not so concerned about me getting severely sick- statistically it’s quite unlikely. I was more concerned about all of those more vulnerable and potential mutations creating a more virulent or dangerous strain. I think that’s how young, healthy people need to look at this.
I think that the more time passes, the more people that right now don't want a vaccine will just do it, especially if the "trial" is over and we get something more... final.

I think it would be interesting if Insurance companies tried to tell their subscribers if you’re eligible and not vaccinated by D-date, we won’t cover your healthcare costs if you’re hospitalized for COVID.
Oh my, this would be an awful legal precedent.
 
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Very alarming all the data coming out of Europe regarding the % of fully vaccinated individuals being hospitalized and dying. Also very alarming how the most masked and vaccinated countries continue to have outbreaks. Sad how peer-reviewed research is continuously censored. The last of a public debate about the science is scary. Science is meant to be discussed and debated. Can someone me to the last U.S data on "Break through cases"? Also, can someone point out the CT level for current PCR tests? As well as the false positive %? Love to hear what the majority of the country has to say
 
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