No; I need the standard pointer for fidelity when mixing audio (same reason I have the higher screen resolution - more real estate for onscreen controls). It would be comical to try using a larger pointer in this scenario.
For me the resize handles are the same size as the regular pointer. If I rotate the regular pointer (which is pointing up to the left) to be horizontal, I get the same horizontal extent as the resize handle used on the side of windows. Maybe the resize handles before Tahoe were larger than the normal pointer. Good luck.
I do remember in Sequoia having all sorts of issues for a while with getting the mouse pointer to change to a resize one. I haven't seen that with Tahoe until just today when I started playing with the size (and before restarting the apps that were affected by that).
I will say that I reboot every morning. That means all of my applications are restarted daily. I've found that is the only way to survive software from less than stellar developers. If you're having an issue with the mouse pointer in a particular application, have you tried to restart the application to see if that resolves it?