a couple observations:
-I take back what I said about the nanotechnology theory, it isn't far fetched at all. apparently the domain name smartdust.com has been registered, smartdust referring to computer controlled nanoparticles. this could be all smoke and mirrors, but it may be the right track. perhaps the 'infection' is the nanotechonogy and the vaccine is something that causes the nano particles to die within the body. not sure how that fits into the idea of the giant psychological experiment (which i'm convinced of, due to the Skinner box) but it's interesting anyway.
-also, the thing about the Black Rock/Magnus Hanso has me intriued to no end. IMO Magnus was an early explorer who crashed his ship on the island, discovering Joop and something special about the place, somehow he got off and later fathered a line of ancestors leading to the Hanso we know and love. I'm a colonial historian so this part is immensely interesting to me