I was fighting a Core i7 with 12 GiB for almost 2 years. Finally decided this spring that the 4 GiB DIMMs had dropped enough in price, and upgraded to 24 GiB.
Great for a few months, now I'm starting to get into serious paging situations - but my chipset won't support 48 GiB.
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You could try one of these:
http://store.apple.com/us/configure/Z0M4?mco=MTg2OTQ5OTk