Did you disconnect all USB devices before running Software Update and installing 10.4.10?
Did you have any USB devices physically connected (powered on or off, mounted or not) while running Software Update and installing 10.4.10?
No. I left it in while the update ran. I went as far to do a "Archive and Install" that didn't help at all. I have a seven port usb hub 100gig usb HD and a Dazzle card reader. They were all on at the time