The EU is already knocking on Apple's door for being a monopoly in the online music world. Microsoft was being dragged through the mud for nothing more than bundling a freaking web browser with Windows. Microsoft never said only IE can run on Windows, we will block Firefox. All they did was include their browser in Windows and a few years later and millions of dollars in legal fees they're still in court!
It doesn't matter that Apple invented iTunes/iPod one bit, they're by far in first place when it comes to online music and some court somewhere is going to soon have a problem with that. Apple would be best to play nice and not rattle any cages.
Honestly, there are tons of media sync applications out there that'd work great with the Pre. iTunes without the store really isn't that feature rich. If I didn't own an iPhone, I wouldn't use iTunes personally. I'm switching my iPhone to a Pre and porting my number to Sprint tomorrow. Since all my music is already synced via iTunes I'll simply use it, but rest assured I'm not upgrading my iTunes until I confirm it's Pre safe.

When I upgrade to Win7 I'm not installing iTunes on it and I'll use something else like Mediamonkey.
Besides, it's not like anybody was sitting around thinking "Gee, I was going to buy a Pre until I found out it doesn't work with iTunes".