yes, there is no problem with macOS scaling 2x to either 6K resolution but there is a bug in macOS where DSC is not working with 6144 x 3456 resolution and DP1.4 connection. That means when you use DP1.4 port you can't get HDR but also (and this could be even more important for someone) you can't get full 6144 x 3456 resolution in RGB 4:4:4 mode. Only 4:2:2 chroma subsampling is available. Which is ok for movies/games but is not very good for some text and small color details.I think there is no problem with macOS scaling 2x to either 6K resolution