I did

(64GB SG) .. I'm at the dreaded 'reading glasses' stage so really wanted the larger screen to work out for me but was ( beforehand) concerned it might be too big! .. It arrived Saturday morning and I LOVE IT! .. I had the 5S before but this is a real step forward.
It is big, there is no avoiding that but I was surprised that it doesn't feel 'too' big .. I have giant stretchy fingers (piano player!!) and I reach the screen fine, it's a little trickier with one hand but I hardly use a phone for the phone bit!!
Most women (I think?!) carry their phones in a bag rather than a pocket but this does fit into the same pocket my 5S was put into and it's not really awkward in there (surprisingly!)
My kids think it's hilarious as a couple of years back I was loudly saying how idiotic the 'phablet' form looked and yet here I am .... BUT .. I am sure (and it's not just because I'm an Apple fangirl I don't think?!?!?) the fact that the 6 Plus is narrow makes a huge difference. It's more than manageable and I am loving being able to see everything so much more clearly!!! The 'pinch to zoom' was getting really old on my 5S!
My advice would be to give the 6 Plus a go. I looked at them in CarphoneWarehouse on Friday and if I'd seen one before ordering I don't think I'd have gone and ordered because it did look huge but actually using one was/is different.
I realise though that it won't be for everyone

but I'm so glad I gave it go (I was prepared to go down to the smaller screen if I'd struggled)
Hope this helps!