Going on 4 months with my Nexus One and haven't looked back once.
Going on 7 months with my Motorola Droid and I am also very happy. I know there are some iPhone fans here that will try to scare you and persuade you that Android is some big scary hard to use OS. It's not. It's easy to use and very intuitive. If you can use an iPhone you can use an Android phone.
I looked at a new Droid X today. It's a great looking phone and I bet you can hold it any way you want and still get a great signal.