My issue isn't as much with a wire running across my desk (which by the way, yes, does bother me that much b/c I guess I'm a sucker for aesthetics), but the fact that I need to control things from my bed.What I don't get is wireless keyboards. Does a wire running across your desk REALLY bother you that much?
For instance, I have my MBP in clamshell mode on a 37'' LCD, which I use as my monitor for viewing movies, websites, etc. My bed is about 7 ft. away from the MBP and screen, thus, I need a wireless keyboard to control the MBP. The wired doesn't stretch that far, and even if it did, it's cord would be extremely annoying and dangerous to my fiancee and dog if it were in the way.
Bottom line, wireless keyboards DO serve a purpose.