Sure, Hulu.com, Amazon new streaming offering (they take on Netflix, Apple TV and iTunes with this), the new Amazon Music Cloud (they beat Apple on cloud music), the Amazon AppStore (yep, they dared), the entire trading platform from Morgan Stanley that is the interface used by clients and brokers around the world, same with UBS and probably half of Wall Street investment banks, the Wall Street Journal application, the BBC player, Flash is also turned into an industry standard by VMware for cloud computing and virtualization interfaces, the new web tv show from Simon (producer of American Idol) last year was entirely in Flash and entirely inaccessible to iPhone or iPad users, the Youtube player is also one, you think you get it all with HTML5 but you do not, and you especially do not get the millions of embed that will take years to convert and any of the premium videos, and I could keep going for hours, thousands and thousands of anything from stupid games to Fortune 100 business critical applications, the whole spectrum.
This is just a few of the big companies actively recruiting Flash, Flex and AIR developers by the dozens, just based on the offers that passed through my desk within the last 60 days:
CNN, ATT, T-Mobile, Sysco, HP, Motorola, Intuit, Hitachi, Google, VMware, Disney, Warner Brothers Studios, Nokia, Morgan Stanley, UBS, Dun & Bradstreet, Roundarch, Lab49, Cynergy Systems ...