I've said this before and I will say this every year with a new major update: I've never had any major problems or bugs with new releases. Why? I always, always RESTORE AND SET UP AS NEW. new OS? Let's make sure your data was created in that environment to work. Most specifically with battery drain issues.
Set up my iPhone 6 as new and synced all my stuff over iTunes/iCloud and downloaded my apps manually, I've been seeing about 2 day battery.
Yeah, unfortunately this is not the answer. I'm sure many do the same thing. I certainly did. Fresh install as a new phone, downloaded only synced contacts / etc from iCloud, manual app re-download.
I'm not sure that I'm having battery issues per se (though battery life on my 6+ is "not better" than the 5 I was using before). However I've seen many of the other bugs described here, including getting stuck in landscape mode, "pausing" or appearing to lock up for ~30 sec in several applications (notably settings, safari), weirdness with the status bar appearing or not appearing in various apps, etc. I'm certainly running into more bugs and flakiness than I did with previous ".0" releases.