iTunes + iPod has been a self-contained ecosystem since the iPod was launched. Yes, there was some early support for a couple other early MP3 players, but that was nixed when Apple created the iPod. That ecosystem has been self-contained since (much like Microsoft's Zune ecosystem). Microsoft chose to make Windows Media Player's syncing library available to third parties, but not Zune's. Apple simply has not made a media player that they want to sync other devices with. That is their prerogative.
Blackberry and other device manufacturers have had perfectly good syncing with iTunes libraries via the XML file. There's nothing wrong with using that method, and it's what Palm should've done from day one. Instead, they decided to be clever and gank an Apple USB device ID to fool iTunes into treating the Pre like it was an iPod. Risky.
The up for Palm is they could potentially take Apple to court for preventing interoperability—assuming they have the money and the time to do so. Seems to me that Palm is in the weak position here. They hacked in functionality that was likely to break without asking permission, and they're in a market position that doesn't give them a lot of leeway (they bet the farm on the Pre, just look at their balance statements). Plus, they've got a ton of ex-Apple employees, so it seems to me that'd cast some questionable light on their reverse-engineering process in any court case.
Still, everyone knew this would be killed. Apple has used their market leader position to drive down the prices of their own hardware (iPods are competitive with other products across the board) and to win DRM-free music for consumers (although individual song prices took an upwards hit as a result, though that's more the record labels' cartel position than anything else). I'd say they're not behaving like a vicious, anti-consumer monopoly.
Palm had the opportunity to do this the "right" way from day one. They didn't.
It had nothing to do with Apple being a monopoly. It is an investigation into Apple having different prices on various EU iTunes stores and prohibiting EU citizens from being able to purchase from another EU store.
That case has everything to do with intellectual property licensing rights and record companies, and very little to do with Apple. Without one unified "European" set of record labels (each label has separate offices/licensing/copyright arrangements in each EU nation), Apple is unable to allow cross-country purchasing.