Sure.
What apps running? - typically I have dozens of Safari tabs open (sometimes lots more - bad hygiene, I know), Word and/or Excel, Messages, Fantastical, Adobe Acrobat Pro and iTunes. Not a crushing load except that have 40, 60 or more tabs open can really burden both the CPU and memory, depending on what's open.
Both were, as I recall (it was a year ago), using about the same absolute amount of memory, rather than the same percent of fixed memory. So there appeared to be little benefit for me in going from 8gb to 16gb. YMMV, though.
I didn't notice any performance improvements. Again, YMMV.
That sure is a LOT of tabs