I have 2 platforms. OS X and Linux for Engineering work and development. Both are OpenGL/OpenCL focused and Bulldozer will be the next purchase for Animation and FEA.
I'm building it with Corsair
case,
1200 W power supply with
GIGABYTE GA-990FXA-UD7 AM3+ AMD 990FX SATA Motherboard alone which runs me over $700 before the RAM, GPUs and CPU.
The rest of the cost will be Bulldozer, 32GB of RAM and GPUs.
Buying a similar Mac Pro with Xeons will be more but not by a large margin.
An AMD 6990 GPU runs over $700 at Newegg. The 6970 jumps me back down to $350. If I'm serious about OpenCL I'm buying 2 of them. so I'm back up to $700+.
With the Bulldozer CPU and RAM I'm back up around 2k+ I assemble myself.
If I were to build the same with Dell or HP it's over 3k, if possible to build one.
The first Opteron 4200/6200 12-core Bulldozer chips are arriving at the end of September.
I'll have more interest in Apple's Mac Pro when there is the option to BTO for either Intel or AMD. I'd rather buy a few Mac Minis for XCode development and only after I need the extra horses after I've bought the Bulldozer box will I invest in the Mac Pro.
I see all three needed for my goals, but all in due time.