My prediction is that Phil Schiller will be making several BIG announcements. I'm giving you all the specificity of a typical TV psychic. There will be "several" and they will be "big."
The last time I saw Jobs speak, he acted more as a master of ceremonies (or emcee or MC, to you youngsters!) than as the one-man show he used to do. He trotted up many others to discuss different things.
Also, there have been many of these big speeches that have been duds, partly because nothing really exciting was revealed and partly because the rumor mill was exactly right and stole Jobs' thunder.
My psychic revelation is based on the idea that if Apple wants to pull off this changing of the guard (at least replacing Jobs as the public face of Apple), they have to give Schiller some killer material to ease the sting of not seeing our hero.